![]() ![]() “In summary, comparative data on trials of the new LAMA/ LABA FDC inhalers against one of the ICS/LABA combination inhalers (fluticasone plus salmeterol) are now available, and the results significantly favor the LAMA/ LABA inhalers in terms of efficacy (improvements in FEV1), patient-reported outcomes (TDI, mMRC), and quality of life measures (SGRQ),” concluded the study. Therefore, LAMA/LABA FDC is a more cost-effective option because of the reduction in long term adverse effects, including exacerbations, and the unpredictability of how much they can cost a COPD patient over time. ![]() LAMA/LABA inhalers decrease the risk of pneumonia by 33% to 67%, according to the analysis. “The new LAMA/LABA FDCs are now widely available and are a welcome addition to the options available for maintenance therapy in COPD.” “Given the significant adverse effects and increased incidence of pneumonia with long-term use of ICS, a favorable efficacy and safety profile of new LAMA/LABA FDCs versus ICS/LABA in COPD patients is very encouraging,” noted the researchers. Pnemonia rates, forced expiratory volume in 1 second (FEV 1), and other adverse events were also considered, and significant improvements were established in favor of the LAMA/LABA inhaler for COPD treatment. Annual exacerbation rates among participants treated with indacaterol/glycopyrronium, one type of LAMA/LABA inhaler, were lower than the fluticasone/salmeterol group in a study. The analysis found significant decreases in exacerbation rates in the long duration trials with the dual bronchodilator. Long-term use of ICS has demonstrated increased incidence of pneumonia and other adverse effects. The new long-acting muscarinic antagonist and long-acting beta-agonist (LAMA/LABA) fixed dose combination (FDC) inhaler may be a better option than inhaled corticosteroids (ICS) for long-term use.Ī new review published by Dove Press analyzes data from previous studies that draw comparisons between new therapies and ICS/LABA. As combination LABA/LAMA inhalers are now widely available, there is a need for well-designed RCTs to investigate whether ICS provides any added therapeutic benefit.As more long-term therapies for chronic obstructive pulmonary disease (COPD) are being developed, the results and efficacy of different therapies vary. There are currently no studies published assessing the effect of ICS in addition to combination LABA/LAMA inhalers for the treatment of stable COPD. ![]() Six studies were identified as potentially relevant however, all failed to meet the inclusion criteria on full-text assessment or after contacting the corresponding author to clarify study characteristics. Following removal of duplicates, 386 abstracts were assessed for inclusion. ![]() We identified a total of 586 records in our search. We used standard methodological procedures expected by Cochrane. We included parallel-group, randomised controlled trials (RCTs) of three weeks' duration or longer which compared treatment of stable COPD with ICS in addition to combination LABA/LAMA inhalers against combination LABA/LAMA inhalers alone. We also searched, World Health Organisation (WHO) trials portal and pharmaceutical company clinical trials' databases up to 7 Janurary 2016. The LAMA tiotropium (Spiriva Respimat) may be added to the treatment plan for severe asthma. A LAMA can also be added to a LABA and inhaled corticosteroid if better control of your asthma is needed. If an LABA cannot be used, a LAMA along with an inhaled corticosteroid can be an option. We carried out searches using the Cochrane Airways Group Specialised Register of Trials (searched 20 September 2016), Cochrane Central Register of Controlled Trials (CENTRAL 2015, Issue 12) in the Cochrane Library (searched 15 December 2015) and MEDLINE (searched 15 December 2015). These medications are also bronchodilators. To assess the effect of adding an inhaled corticosteroid (ICS) to combination long-acting beta₂-agonist (LABA)/long-acting muscarinic antagonist (LAMA) inhalers for the treatment of stable COPD. However, the benefits and risks of adding ICS to combination LABA/LAMA inhalers remains unclear. LABA and LAMA bronchodilators are now available in single combination inhalers. In individuals with persistent symptoms or frequent exacerbations, inhaled corticosteroids (ICS) are also used. Management of chronic obstructive pulmonary disease (COPD) commonly involves long-acting bronchodilators including beta-agonists (LABA) and muscarinic antagonists (LAMA). ![]()
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